Long-term response to recombinant human growth hormone therapy in Indian children with growth hormone deficiency
نویسندگان
چکیده
منابع مشابه
Long-term safety of recombinant human growth hormone in children.
BACKGROUND Between 1985 and 2006, the National Cooperative Growth Study (NCGS) monitored the safety and efficacy of recombinant human growth hormone (rhGH) in 54,996 children. METHODS Enrolled patients were followed until rhGH discontinuation. Investigators submitted adverse event reports for targeted events or those potentially rhGH-related. RESULTS Early concerns about de novo leukemia in...
متن کاملLong-term follow-up results of growth hormone therapy for patients with adult growth hormone deficiency.
OBJECTIVE We evaluated the long-term effects of growth hormone (GH) on markers of quality of life, glucose metabolism, and lipid metabolism to validate the adequacy of long-term GH replacement therapy for adult GH deficiency (AGHD). DESIGN Eighty-three of 100 sequentially followed patients who received GH therapy were selected for this study. Forty-nine were men aged 26 to 78 years (mean, 52 ...
متن کاملFive-year response to growth hormone in children with Noonan syndrome and growth hormone deficiency
BACKGROUND Noonan syndrome (NS) is an autosomal dominant disorder characterized by specific features including short stature, distinctive facial dysmorphic features, congenital heart defects, hypertrophic cardiomyopathy, skeletal anomalies and webbing of the neck. Molecular screening has shown that the majority of individuals with NS have a mutation in the PTPN11 gene. Noonan syndrome children ...
متن کاملLong-term efficacy of recombinant human growth hormone therapy in short-statured patients with Noonan syndrome.
PURPOSE Noonan syndrome (NS) is characterized by short stature, heart anomalies, developmental delays, dysmorphic features, cryptorchidism, and coagulation defects. Several studies reported the short-term effects of recombinant human growth hormone (rhGH) treatment on the improvement of height. This study was performed to evaluate the long-term efficacy of rhGH in children with NS in Korea. M...
متن کاملEffects of recombinant human growth hormone therapy on bone mineral density in adults with growth hormone deficiency: a meta-analysis.
OBJECTIVE GH deficiency is associated with decreased bone mineral density (BMD) and increased fracture risk. Because the effects of recombinant human GH (rhGH) therapy on BMD and bone mineral content have not been systematically investigated, we conducted a meta-analysis of pertinent studies. DESIGN A thorough search of the literature (MEDLINE, EMBASE, and the Cochrane Register) was performed...
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ژورنال
عنوان ژورنال: Indian Journal of Endocrinology and Metabolism
سال: 2019
ISSN: 2230-8210
DOI: 10.4103/ijem.ijem_300_19